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KMID : 1145520200060010039
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Journal of Radiopharmaceuticals and Molecular Probes
2020 Volume.6 No. 1 p.39 ~ p.45
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Radiolabeled single-domain antibody for tumor receptor imaging
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Moon Yea-Jin
Lee Ju-Young
Ryoo Woon-Seok
Seo Seung-Yong
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Abstract
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Recently, single-domain antibodies (sdAb) are bioengineered for molecular imaging applications. Singledomain antibody, obtained from naturally occurring antibodies in camelid species and cartilaginous fish is the smallest fully functional antigen-binding antibody fragments of heavy-chain. Since their discovery, they have been investigated extensively in clinical therapeutics, monitoring and diagnostics. Their small size is important advantage for high solubility, high stability, fast blood clearance and rapid targeting. This review article summarizes the recent status of this new antibody to visualize, diagnose or inhibit specific targets of cancer.
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KEYWORD
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single-domain antibody, camelid VHH, cancer, molecular imaging
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